Grishkevich V M
Kardiologiia. 1975 Sep;15(9):122-6.
On the basis of a study of the sound pattern and of the data of right and left heart catheterization it has been established that the presystolic accentuation of the mitral diastolic murmur in atrial fibrillation is predisposed by the peculiarities of the dynamics of the left ventricular diastolic pressure. When the diastole is becoming shorter, the diastolic pressure does not grow gradually, as it happens under normal conditions, but progressively decreases during the whole period of the diastole which causes the appearence of a pressure gradient across the atrioventricular orifice, increasing during the diastole, an increasing diastolic blood flow rate through the mitral valve and, as a consequence, an accentuation of the mitral diastolic murmur during the diastole.
基于对心音图以及左右心导管检查数据的研究，现已证实，房颤时二尖瓣舒张期杂音的收缩期前增强是由左心室舒张压的动态变化特点所诱发的。当舒张期变短，舒张压并非如正常情况下那样逐渐升高，而是在整个舒张期内逐渐降低，这导致房室口出现压力阶差，且在舒张期逐渐增大，二尖瓣的舒张期血流速度增加，结果是二尖瓣舒张期杂音在舒张期增强。
