在毕赤酵母发酵罐培养物中生产重组蛋白。
Production of recombinant proteins in fermenter cultures of the yeast Pichia pastoris.
作者信息
Cereghino Geoff P Lin, Cereghino Joan Lin, Ilgen Christine, Cregg James M
机构信息
Department of Biological Sciences, University of the Pacific, 3601 Pacific Avenue, Stockton, California 95211, USA.
出版信息
Curr Opin Biotechnol. 2002 Aug;13(4):329-32. doi: 10.1016/s0958-1669(02)00330-0.
Abstract
The Pichia pastoris expression system offers economy, ease of manipulation, the ability to perform complex post-translational modifications, and high expression levels. Using this system, recent advances have been made in the quality of recombinant proteins in fermenter culture and in the quality of the protein product, namely improved secretion signals and glycosylation patterns.
摘要
毕赤酵母表达系统具有成本低、易于操作、能够进行复杂的翻译后修饰以及表达水平高的特点。利用该系统，在发酵罐培养中重组蛋白的质量以及蛋白产品的质量方面都取得了新进展，即改进了分泌信号和糖基化模式。
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