Giardina C, Guerrieri A M, Ingravallo G, Serio G, Mastropasqua M G, Lomele M, Lattanzio V
Dipartimento di Anatomia Patologica e di Genetica (DAPEG), Policlinico Universitario, Piazza G. Cesare 11, I-70124, Bari, Italia.
Pathologica. 2002 Aug;94(4):182-9. doi: 10.1007/s102420200029.
The aim of this work was to evaluate the accuracy of vacuum-assisted biopsy by comparing it with frozen biopsy. 141 stereotaxic biopsies were performed by Mammotome (Ethicon Endo-Surgery, Hamburg) from January 2000 to March 2001. Biopsies were performed for microcalcifications (n = 105, 74.5%), irregular opacities (n = 20, 14.2%), regular opacities (n = 6, 4.2%), stellate lesions (n = 10, 7.1%). Histological analysis showed 85 (60.3%) benign lesions, 46 (32.6%) malignant lesions including (21 cases of carcinoma in situ and 25 invasive carcinomas) and 10 (7.1%) atypical lesions. All malignant lesions were subjected to surgery. In three cases (1 in situ and 2 invasive), core biopsy was excisional and no residual lesion was observed. Two of the carcinomas in situ revealed invasive features on the surgical biopsy. One of the atypical lesions was underestimated and the final diagnosis was "well differentiated carcinoma in situ." Only three of benign lesions underwent surgery after Mammotome biopsy. Among the 55 frozen-section biopsies of mammographically detected breast lesions performed in the same period, were one false-positive and 3 false-negative cases, while in 4 cases the diagnosis was deferred after paraffin embedding. Our results confirmed Mammotome biopsy as an effective alternative and a more reliable method than frozen-section examination.
本研究旨在通过与冷冻活检相比较，评估真空辅助活检的准确性。2000年1月至2001年3月期间，使用Mammotome（Ethicon Endo-Surgery，汉堡）进行了141例立体定向活检。活检针对微钙化（n = 105，74.5%）、不规则致密影（n = 20，14.2%）、规则致密影（n = 6，4.2%）、星芒状病变（n = 10，7.1%）进行。组织学分析显示85例（60.3%）为良性病变，46例（32.6%）为恶性病变，包括21例原位癌和25例浸润性癌，10例（7.1%）为非典型病变。所有恶性病变均接受了手术治疗。在3例（1例原位癌和2例浸润性癌）中，粗针活检为切除性活检，未观察到残留病变。2例原位癌在手术活检时显示有浸润特征。1例非典型病变被低估，最终诊断为“高分化原位癌”。在Mammotome活检后，只有3例良性病变接受了手术。同期对乳腺钼靶检查发现的乳腺病变进行的55例冷冻切片活检中，有1例假阳性和3例假阴性病例，4例在石蜡包埋后诊断延迟。我们的结果证实，Mammotome活检是一种有效的替代方法，比冷冻切片检查更可靠。
