Castenfors H, Hedenstierna G, Glenne P O
Eur J Clin Pharmacol. 1975 Apr 4;8(3-4):197-200. doi: 10.1007/BF00567114.
Terodiline chloride, 150 mg daily, was administered to 10 patients with obstructive pulmonary disease, and pulmonary function tests were performed before and during two weeks of therapy. Serious side effects of anticholinergic type developed in two patients who stopped treatment. Two patients were excluded from the trial for other reasons. The remaining six patients showed signs of bronchodilation. Owing to the high incidence of side effects, treatment with more than 75 mg terodiline chloride per day is impracticable.
对10例阻塞性肺病患者给予每日150毫克的氯特罗定，并在治疗前及治疗两周期间进行肺功能测试。两名出现抗胆碱能类严重副作用的患者停止了治疗。两名患者因其他原因被排除在试验之外。其余六名患者出现支气管扩张迹象。由于副作用发生率高，每日使用超过75毫克氯特罗定进行治疗是不可行的。
