Higher unit dosage of psychotropic drugs.

The questions involved in higher unit dosage of psychotropic drugs are made concrete in writing the Dosage and Administration Section of package inserts for drugs. The author outlines a number of problems in recommending specific changes in conventional dosage regimens. He suggests that a major reason for reluctance to adopt new regimens using less frequent dosing is the relative paucity of data demonstrating that less frequent, higher dosing is as effective as conventional regimens. Intrinsic methodological and pharmacological problems make it difficult to generate such data for psychotropic drugs. Nonetheless, recommendations for less frequent, higher, psychotropic dosage regimens will become more common in package inserts.