Govorova L V, Aleksandrova E A, Teplov S I
Vopr Med Khim. 1975 Jan-Feb;21(1):23-6.
An effect of hypoxic hypoxia on the total, Mg2+-dependent and Na-K-dependent ATPase activities was studied in rat brain and erythrocytes. In brain tissue under effect of 15 min hypoxia a distinct decrease in all the ATPase activities was observed; the activity of Na-K-dependent ATPase decreased especially distinctly (by 32% of the initial level). Within 90 min of hypoxia the enzymatic activity was partially restored but did not reach the initial level. In erythrocytes 15 min hypoxia was also accompanied by a significant decrease in Na-K-dependent ATPase activity (30.5% of the initial level). But within 90 min the enzymatic activity was distinctly increased (up to 196.4%). Mg2+-dependent ATP-ase was more resistant to oxygen deficiency, Variations in the enzymatic activity were less distinct, although they showed the same pattern as those of the Na-K-dependent ATPase.
研究了低氧性缺氧对大鼠脑和红细胞中总ATP酶、Mg2+依赖性ATP酶和Na-K依赖性ATP酶活性的影响。在15分钟缺氧作用下的脑组织中，观察到所有ATP酶活性明显下降；Na-K依赖性ATP酶的活性下降尤为明显（降至初始水平的32%）。在缺氧90分钟内，酶活性部分恢复，但未达到初始水平。在红细胞中，15分钟的缺氧也伴随着Na-K依赖性ATP酶活性的显著下降（降至初始水平的30.5%）。但在90分钟内，酶活性明显增加（增至196.4%）。Mg2+依赖性ATP酶对缺氧更具抗性，酶活性的变化不太明显，尽管其变化模式与Na-K依赖性ATP酶相同。
