用1-去氨基-8-D-精氨酸加压素治疗尿崩症。
Treatment of diabetes insipidus with 1-deamino-8-d-arginine vasopressin.
作者信息
Czakó L, Mezei G, László F A
出版信息
Acta Med Acad Sci Hung. 1975;32(1):75-84.
The effect on water metabolism of 1-deamino-8-D-arginine vasopressin and lysine vasopressin have been studied and compared in 20 vasopressin-sensitive and 2 ADH-resistant diabetes insipidus patients. In every case of ADH-sensitive diabetes insipidus, diuresis decreased and the urinary osmolality increased more markedly and for a longer time with the former than with the latter drug. Both drugs were ineffective in patients with ADH-resistant diabetes insipidus. Administration of 1-deamino-8-D-arginine vasopressin did not cause any side effect. It is concluded that 1-deamino-8-D-arginine vasopressin can successfully be employed in the treatment of ADH-sensitive diabetes insipidus.
对20例血管升压素敏感型和2例抗利尿激素（ADH）抵抗型尿崩症患者，研究并比较了1-去氨基-8-D-精氨酸血管升压素和赖氨酸血管升压素对水代谢的影响。在每例血管升压素敏感型尿崩症患者中，与后一种药物相比，前一种药物使尿量减少，尿渗透压升高更显著且持续时间更长。两种药物对ADH抵抗型尿崩症患者均无效。给予1-去氨基-8-D-精氨酸血管升压素未引起任何副作用。得出结论，1-去氨基-8-D-精氨酸血管升压素可成功用于治疗血管升压素敏感型尿崩症。
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