Secretin-like activity in duodenal mucosa and peptic ulcer.

The secretin-like activity contained in bioptic specimens of duodenal mucosa was measured by means of bioassay in healthy controls and patients of peptic ulcer. It was found that the activity tended to be increased in duodenal ulcer in comparison with gastric ulcer which did not differ from healthy controls. Possibilities of impaired release and/or increased production of secretin-like substance in duodenal ulcer were discussed.