Tsoneva M T, Penchev P R, Karev G B, Gishin S S
Genetika. 1975;11(3):153-7.
An effect of stable magnetic field on karyotype and cell division of human lymphocytes from peripheral blood was studied in tissue culture. Comparative investigations were carried out with lymphocytes, which were treated with magnetic field of different tension (0,179; 0,391 and 0,600 Ts) and continuance (30 sec, 30 and 60 min). Lymphocytes, treated with stable magnetic field, were suspended in donor plasma and immediately cultivated after the treatment. The stable magnetic field was found to have a distinct mutagenic effect on cultivated lymphocytes of human peripheral blood. The increase in structural impairements of chromosomes correlated with tension of magnetic field and continuance of its effect. In structural impairements of chromosomes the chromatid gaps and breaks were more often observed but chromosome ruptures and pericentric clearances occurred more rarely. The effect of stable magnetic field on lymphocytes proliferation was studied. Under weak and transient using of magnetic field the proliferation was stimulated, but in rigid conditions - mitosis and blastic transformation were decreased. Continuous effect of magnetic field with weak tension did not inhibite the blastic transformation but influenced on the survival rate of cells in tissue culture, enhancing their lethality.
在组织培养中研究了稳定磁场对人外周血淋巴细胞核型和细胞分裂的影响。对用不同强度（0.179、0.391和0.600特斯拉）和持续时间（30秒、30和60分钟）的磁场处理过的淋巴细胞进行了比较研究。用稳定磁场处理过的淋巴细胞悬浮在供体血浆中，并在处理后立即培养。发现稳定磁场对人外周血培养淋巴细胞有明显的诱变作用。染色体结构损伤的增加与磁场强度及其作用持续时间相关。在染色体结构损伤中，更常观察到染色单体间隙和断裂，但染色体断裂和着丝粒间隙较少发生。研究了稳定磁场对淋巴细胞增殖的影响。在弱且短暂使用磁场的情况下，增殖受到刺激，但在严格条件下，有丝分裂和原始细胞转化减少。弱强度磁场的持续作用并未抑制原始细胞转化，但影响组织培养中细胞的存活率，提高其致死率。
