17β-雌二醇在预防挛缩形成中的价值。
Value of 17beta-oestradiol in prevention of contracture formation.
作者信息
Akeson W H, Woo S L, Amiel D, Doty D H, Rutherford L
出版信息
Ann Rheum Dis. 1975 Oct;35(5):429-36. doi: 10.1136/ard.35.5.429.
Male and female rabbits were treated with 17beta-oestradiol during the 9-week development of a contracture in the left hind limb. The right hind limb served as the paired control. Untreated (absolute control) animals received saline injections. After 9 weeks biochemical analyses of water, hexosamine, soluble and total collagen, as well as biomechanical measurements of joint stiffness, were performed on the dissected knees. In all cases 17beta-oestradiol reduced the measured stiffness in the contractures by approximately 50% as compared to the contractures of the untreated animals. 17beta-oestradiol, in addition, partially prevented the loss of water and hexosamine which occurs in untreated contractures. 17beta-oestradiol administration also decreased the content of soluble collagen fractions in the periarticular connective tissue of both the control and experimental knees. The relationship of these biochemical findings to their mechanical consequences is discussed, and the results are related to a working hypothesis of stress- and motion-dependent homoeostasis within periarticular connective tissue.
在左后肢挛缩的9周发展过程中，对雄性和雌性兔子进行17β-雌二醇处理。右后肢作为配对对照。未处理（绝对对照）的动物接受盐水注射。9周后，对解剖后的膝盖进行水、己糖胺、可溶性和总胶原蛋白的生化分析，以及关节僵硬程度的生物力学测量。在所有情况下，与未处理动物的挛缩相比，17β-雌二醇使挛缩中测得的僵硬程度降低了约50%。此外，17β-雌二醇部分阻止了未处理挛缩中发生的水分和己糖胺的流失。给予17β-雌二醇还降低了对照膝和实验膝关节周围结缔组织中可溶性胶原蛋白组分的含量。讨论了这些生化发现与其力学后果之间的关系，并将结果与关节周围结缔组织内应力和运动依赖性稳态的工作假设相关联。
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