Imaizumi K, Shigemi U, Nakamura M
Paroi Arterielle. 1975 May;2(4):213-9.
The purpose of our experiments was to clarify the relationship between the susceptibility to atherosclerosis and chemical composition in the human cerebral, coronary arteries and aorta, and the concentration and composition of human arterial intimal elastic tissues were measured. In the cerebral arteries, the concentration of hot alkali-insoluble elastin was higher than that of the coronary arteries and aortas, and gradually decreased with age. Age-related changes of the elastin in the coronary arteries were quite small. The total polar amino acids and crude ash contents of arterial elastins were affected by age and treatment of elastic tissue wheteher or not EDTA-decalcification was applied prior to alkali-extraction. No significant differences in the amino acid composition of elastin was founded between the cerebral, coronary and aortic intimas and no significant changes to elastin, and or collagen, which can explain the slow development of atherosclerosis in the cerebral artery, were founded. Therefore, from these results, the slower development rate of cerebral atherosclerosis, as compared with other arteries, can not be sufficiently concluded.
我们实验的目的是阐明人类脑动脉、冠状动脉和主动脉中动脉粥样硬化易感性与化学成分之间的关系，并测量人类动脉内膜弹性组织的浓度和成分。在脑动脉中，热碱不溶性弹性蛋白的浓度高于冠状动脉和主动脉，且随年龄增长逐渐降低。冠状动脉中弹性蛋白的年龄相关变化相当小。无论在碱提取前是否进行EDTA脱钙处理，动脉弹性蛋白的总极性氨基酸和粗灰分含量都受年龄和弹性组织处理的影响。在脑动脉、冠状动脉和主动脉内膜的弹性蛋白氨基酸组成上未发现显著差异，也未发现弹性蛋白和（或）胶原蛋白有显著变化，而这些变化本可解释脑动脉中动脉粥样硬化发展缓慢的原因。因此，从这些结果来看，并不能充分得出与其他动脉相比，脑动脉粥样硬化发展速度较慢的结论。
