Aleksidze N G, Balavadze M V
Vopr Biokhim Mozga. 1975;10:97-106.
In rats learning to use nonpreferred paw is accompanied by an increase of acetylcholinesterase (AChE) of specific areas of rat cerebral cortex and pyramidal neurones of CA3 and CA4 of the hippocampus. Following achievement of new behavioural reactions high AChE activity is preserved longer in the neacortex, the enzyme activity in the pyramidal neurones of the hippocampal cortex coming to normal. Following preliminary intracranial administration of puromycin the increase of AChE activity during learning is no more observed. This indicates the activation of the genetic apparatus during learning and training as a result of which synthesis of membrane proteins including AChE is enhanced. A close correlation between learning and the inductive synthesis of AChE is observed. Lateralization of the chemical traces of learning in specific areas of rat cerebral cortex are observed as increased activity of AChE. Changes in AChE activity in various hemispheres of rat brain during learning are thought to be due to assymetric changes in the excitatory level of cortical sites during the formation of new behavioural reactions. The specific localization of biochemical changes in the brain is certainly more favorable from an energetic aspect and may by regarded as an evolutionary compensatory process. The interrelationship of the activation of the synthetic apparatus of the cell with the reception of external informations is one of the expressions of adaptation during codations of functions of the organism more advantageous from an evolutionary point of view.
在大鼠学习使用非优势爪的过程中，其大脑皮层特定区域以及海马体CA3和CA4区的锥体神经元中的乙酰胆碱酯酶（AChE）会增加。在获得新的行为反应后，新皮层中较高的AChE活性会保留更长时间，而海马皮层锥体神经元中的酶活性则恢复正常。在预先进行颅内注射嘌呤霉素后，学习过程中不再观察到AChE活性的增加。这表明学习和训练过程中基因装置被激活，结果包括AChE在内的膜蛋白合成增强。观察到学习与AChE的诱导合成之间存在密切相关性。在大鼠大脑皮层特定区域观察到学习的化学痕迹的偏侧化表现为AChE活性增加。学习过程中大鼠大脑各半球AChE活性的变化被认为是由于新行为反应形成过程中皮层部位兴奋水平的不对称变化所致。从能量角度来看，大脑中生化变化的特定定位肯定更有利，并且可以被视为一种进化补偿过程。细胞合成装置的激活与外部信息接收之间的相互关系是生物体功能编码过程中适应性表现之一，从进化角度来看这更具优势。
