Failli Vieri, Bachy Isabelle, Rétaux Sylvie
UPR 2197, Développement, Evolution, Plasticité du Système Nerveux, Institut de Neurobiologie Alfred FESSARD, C.N.R.S., Avenue de la Terrasse, 91198 GIF-sur-YVETTE cedex, France.
Mech Dev. 2002 Oct;118(1-2):225-8. doi: 10.1016/s0925-4773(02)00254-x.
The expression pattern of Lmx1a, a LIM-homeodomain gene disrupted in the dreher mouse neurological mutant, is described during development. Lmx1a is predominantly expressed in the developing nervous system from embryonic day E8.5 to adulthood, in restricted areas. Major expression domains include the dorsal midline (roof plate) of the neural tube, the cortical hem, the otic vesicles, the developing cerebellum and the notochord. The Lmx1a expression pattern is therefore well correlated with the various aspects of the phenotype of the dreher mutant mice.
在发育过程中描述了Lmx1a（一种在dreher小鼠神经突变体中被破坏的LIM同源结构域基因）的表达模式。从胚胎期E8.5到成年期，Lmx1a主要在发育中的神经系统的特定区域表达。主要表达域包括神经管的背中线（顶板）、皮质下托、耳泡、发育中的小脑和脊索。因此，Lmx1a的表达模式与dreher突变小鼠表型的各个方面密切相关。
