Sonkodi S, Rácz O, Bókay P
Acta Physiol Acad Sci Hung. 1975;46(2):107-10.
The effect of actinomycin-D on blood pressure and the renin-angiotensin system has been studied in the rat. Treatment with the drug caused blood pressure, plasma renin activity and plasma renin substrate level to decrease. The results suggest that in the blood pressure-decreasing effect a reduction of the activity of the renin-angiotensin system had a role. This contradicts the view that actinomycin-D has no influence on renin production in the kidney.
已经在大鼠中研究了放线菌素-D对血压和肾素-血管紧张素系统的影响。用该药物治疗导致血压、血浆肾素活性和血浆肾素底物水平降低。结果表明，在降低血压的作用中，肾素-血管紧张素系统活性的降低起到了作用。这与放线菌素-D对肾脏中肾素产生没有影响的观点相矛盾。
