Shibolet Oren, Kalish Yossi, Wolf Dana, Pappo Orit, Laxer Uri, Berkman Neville, Shaham Dorit, Ashur Yaffa, Ilan Yaron
Liver Unit, Department of Medicine, Hadassah-Hebrew University Hospital, Jerusalen, Israel.
J Clin Gastroenterol. 2002 Oct;35(4):356-8. doi: 10.1097/00004836-200210000-00015.
Patients with hepatic sarcoidosis rarely require orthotopic liver transplantation (OLT). Progression of granulomatous activity involving other organs after OLT has rarely been described. We describe a 32-year-old woman who underwent liver transplantation for sarcoidosis-associated end-stage liver disease. She presented 4 years later with shortness of breath, hilar lymphadenopathy, and interstitial lung abnormalities. Liver functions were normal. Open lung biopsy results revealed granulomata compatible with sarcoidosis. The patient made a complete recovery after corticosteroid treatment. To the best of our knowledge, this is a first description of severe exacerbation of pulmonary sarcoidosis in an immunosuppressed patient who underwent liver transplantation for sarcoidosis-associated liver disease.
