Lyckman Alvin W, Sur Mriganka
Center for Learning and Memory, Massachusetts Institute of Technology, E25-235, Cambridge, Massachusetts 02139, USA.
Results Probl Cell Differ. 2002;39:139-56. doi: 10.1007/978-3-540-46006-0_7.
The surgical cross-modal rewiring paradigm is an experimental method for examining the physiological and anatomical consequences of exposing developing cortical subregions to specific types of patterned sensory inputs. Data from these experiments provide strong inferences about the role of extrinsic (subcortical) cortical inputs in shaping the local cortical networks that organize and process sensory information. Behavioral results from this work also suggest that such activity (and activity in general) is a profound organizer of cerebral connectivity. We discuss one future direction of these studies: the implication that extrinsic inputs regulate developmental genes that are responsible for refining the connectivity within local circuits, and a strategy to discover and characterize such genes.
外科跨模态重新布线范式是一种实验方法，用于研究将发育中的皮质亚区域暴露于特定类型的模式化感觉输入所产生的生理和解剖学后果。这些实验的数据为外在（皮质下）皮质输入在塑造组织和处理感觉信息的局部皮质网络中的作用提供了有力推断。这项工作的行为学结果还表明，这种活动（以及一般的活动）是大脑连接性的一个重要组织者。我们讨论这些研究的一个未来方向：外在输入调节负责优化局部回路内连接性的发育基因的这一观点，以及发现和表征此类基因的一种策略。
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