Prats N, López S, Domingo M, Briones V, Domínguez L, Marco A J
Departamento de Sanidad y Anatomía Animales, Facultad de Veterinaria, Universidad Autónoma de Barcelona, 08193, Bellaterra, Barcelona.
J Comp Pathol. 2002 Aug-Oct;127(2-3):178-85. doi: 10.1053/jcpa.2002.0578.
Inoculation of mice with Listeria monocytogenes intragastrically or by parenteral routes has not been reported to cause peritonitis. In this study, however, severe listerial peritonitis was induced in mice infected subcutaneously and treated intraperitoneally with cyclosporin A (Cs A) in an oil carrier. In both uninfected and listeria-infected mice, intraperitoneal administration of Cs A consistently produced overexpression of P-selectin in the peritoneal microvasculature and pyogranulomatous inflammation of the peritoneum, suggesting that Cs A causes endothelial damage. We suggest that in listeria-infected mice the non-specific irritant peritonitis induced by the intraperitoneal administration of Cs A results in transfer of listeria-infected phagocytes from the liver and spleen to the peritoneal microvasculature, producing metastatic infection.
经胃内或非肠道途径用单核细胞增生李斯特菌接种小鼠，尚未见有引发腹膜炎的报道。然而，在本研究中，皮下感染并用油剂载体腹腔注射环孢菌素A（Cs A）的小鼠诱发了严重的李斯特菌性腹膜炎。在未感染和感染李斯特菌的小鼠中，腹腔注射Cs A均持续导致腹膜微血管中P-选择素的过度表达以及腹膜的脓性肉芽肿性炎症，提示Cs A会造成内皮损伤。我们认为，在感染李斯特菌的小鼠中，腹腔注射Cs A诱发的非特异性刺激性腹膜炎会导致感染李斯特菌的吞噬细胞从肝脏和脾脏转移至腹膜微血管，从而产生转移性感染。
