Miles Mary P, Kraemer William J, Grove Deborah S, Leach Sharyn K, Dohi Keiichiro, Bush Jill A, Marx James O, Nindl Bradley C, Volek Jeff S, Mastro Andrea M
Department of Health and Human Development, Montana State University, Bozeman, MT, USA.
Eur J Appl Physiol. 2002 Oct;87(6):506-8. doi: 10.1007/s00421-002-0683-4. Epub 2002 Aug 21.
The aim of this investigation was to determine whether intense resistance training of 6 months duration influenced resting immune parameters. Previously untrained women underwent one of four training programs or were non-training controls (CON, n=7). The resistance-training groups trained for total body power (TP, n=16), total body hypertrophy (TH, n=18), upper body power (UP, n=15) or upper body hypertrophy (UH, n=15). Immune parameters were measured from a fasting morning blood draw in September/October (0 months, t(0)), November/December (3 months, t(3)), and April/May (6 months, t(6)). Lymphocyte subsets [CD4+ T cells, CD8+ T cells, natural killer cells (NK), and B cells], and mitogen-stimulated proliferation were measured. The concentration of NK cells increased ( P<0.001) after 3 months of training for the resistance-training groups but not the CON group. This increase was not present after 6 months of training, thus it was a transient change. Lymphocyte proliferation responses were similar across time for the resistance-trained and CON groups for all stimulation conditions. Thus, resistance training induces a transient increase in NK cells but has little effect on lymphocyte trafficking or proliferation. This was consistent despite differences in the volume of muscle mass trained or the manner of training (power verses hypertrophy).
本研究的目的是确定为期6个月的高强度抗阻训练是否会影响静息免疫参数。之前未受过训练的女性接受了四个训练项目之一或作为非训练对照组（CON，n = 7）。抗阻训练组分别进行全身力量训练（TP，n = 16）、全身增肌训练（TH，n = 18）、上身力量训练（UP，n = 15）或上身增肌训练（UH，n = 15）。于9月/10月（0个月，t(0)）、11月/12月（3个月，t(3)）和4月/5月（6个月，t(6)）采集空腹晨血，检测免疫参数。检测淋巴细胞亚群[CD4 + T细胞、CD8 + T细胞、自然杀伤细胞（NK）和B细胞]以及丝裂原刺激的增殖情况。抗阻训练组训练3个月后NK细胞浓度增加（P<0.001），而对照组未增加。6个月训练后这种增加不再出现，因此这是一个短暂变化。在所有刺激条件下，抗阻训练组和对照组的淋巴细胞增殖反应随时间变化相似。因此，抗阻训练可使NK细胞短暂增加，但对淋巴细胞转运或增殖影响较小。尽管训练的肌肉量或训练方式（力量训练与增肌训练）存在差异，但结果仍是一致的。
