来自 Lourteigia ballotaefolia 的抗炎倍半萜内酯。

Anti-inflammatory sesquiterpene lactones from Lourteigia ballotaefolia.

作者信息

Rosas-Romero Alfredo, Manchado Carlos Martinez, Crescente Oscar, Acosta Mercedes, Curini Massimo, Epifano Francesco, Marcotullio Maria Carla, Rosati Ornelio, Tubaro Aurelia, Sosa Silvio

机构信息

Departamento de Química, Universidad Simón Bolívar, Caracas, Venezuela.

出版信息

Planta Med. 2002 Sep;68(9):843-5. doi: 10.1055/s-2002-34405.

DOI:10.1055/s-2002-34405

PMID:12357402

Abstract

Three sesquiterpene lactones were isolated from Lourteigia ballotaefolia (H. B. K.). 9beta-hydroxy-atripliciolide-8- O-tiglate ( 1) was isolated for the first time from this plant and was previously reported in Conocliniopsis prasiifolia (DC) K. et R., 9beta-hydroxy-atripliciolide-8- O-(5'-acetoxytiglate) ( 2) had been already reported in this species. The minor component, 9beta-(tigloyloxy)-atripliciolide, is a new compound. The anti-inflammatory activity of compounds 1 and 2 was evaluated using the croton oil ear test in mice.

摘要

从Lourteigia ballotaefolia (H. B. K.)中分离出三种倍半萜内酯。9β-羟基-三脉叶内酯-8-O-惕各酸酯（1）首次从该植物中分离得到，此前在Conocliniopsis prasiifolia (DC) K. et R.中有报道，9β-羟基-三脉叶内酯-8-O-(5'-乙酰氧基惕各酸酯)（2）已在该物种中报道过。次要成分9β-(惕各酰氧基)-三脉叶内酯是一种新化合物。使用巴豆油耳部试验在小鼠中评估了化合物1和2的抗炎活性。