无患子科 Decachaeta incompta 中的两个新的 heliangolide 化合物 Incomptines C 和 D 及其抗原生动物活性。

Incomptines C and D, two heliangolides from Decachaeta incompta and their antiprotozoal activity.

机构信息

Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, México City, México.

出版信息

Planta Med. 2012 Oct;78(15):1698-701. doi: 10.1055/s-0032-1315255. Epub 2012 Sep 4.

Abstract

Two new heliangolides, incomptines C (3) and D (4), were isolated from the leaves of Decachaeta incompta. The structures were established by spectroscopic methods and confirmed by X-ray crystallography. The antiprotozoal activity of incomptines C and D was evaluated. Additionally, the chromatographic profile of the leaves and roots extracts were compared to identify incomptines A-D (1-4) in each extract.

摘要

从 Decachaeta incompta 的叶子中分离得到两种新的海良内酯 incomptines C（3）和 D（4）。通过光谱方法确定了它们的结构，并通过 X 射线晶体学得到了证实。评估了 incomptines C 和 D 的抗原生动物活性。此外，还比较了叶子和根提取物的色谱图，以确定每个提取物中的 incomptines A-D（1-4）。