[结合疫苗]
[Conjugate vaccines].
作者信息
Swennen B, Sternon J
机构信息
Unité d'Epidémiologie pédiatrique et Vaccination, Ecole de Santé publique, U.L.B.
出版信息
J Pharm Belg. 2002 Jul-Aug;57(4):73-81.
Conjugate vaccines extend the vaccinal prevention for children to more diseases. Conjugating the capsular polysaccharide to a carrier protein transforms a T-independent antigen in a T-dependent, allowing protection of the children (before 2 years of age) against Haemophilus influenzae type b, meningococcal C and pneumococcal infections. This article reviews the 3 conjugate vaccines and their results with focus on some questions: antigens interference in the immunological response, serological subrogate for protection, herd immunity and replacement of circulating serotypes.
结合疫苗将儿童疫苗预防的疾病范围扩大到更多疾病。将荚膜多糖与载体蛋白结合可将非T细胞依赖性抗原转化为T细胞依赖性抗原，从而使2岁以下儿童能够预防b型流感嗜血杆菌、C群脑膜炎球菌和肺炎球菌感染。本文综述了这三种结合疫苗及其效果，重点关注以下几个问题：抗原对免疫反应的干扰、保护的血清学替代指标、群体免疫以及流行血清型的替代。
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