Gessner Bradford D, Adegbola Richard A
Agence de Médecine Préventive, Institut Pasteur, 28 rue du Doctor Roux, F-75724 Paris, France.
Vaccine. 2008 Jun 16;26 Suppl 2:B3-8. doi: 10.1016/j.vaccine.2008.04.013.
This article explores key lessons learned from vaccination with Haemophilus influenzae type b (Hib) conjugate vaccine and how these lessons may provide insight into the impact of emergent pneumococcal vaccines against pneumonia. The worldwide value of Hib vaccination for reducing Hib disease burden and carriage is reviewed. Using comparisons of data for pneumococcus versus Hib, the article concludes that epidemiological and biological differences between these pathogens will complicate efforts to use results from the Hib vaccine experience to predict outcomes following pneumococcal conjugate vaccine introduction.
本文探讨了从b型流感嗜血杆菌（Hib）结合疫苗接种中吸取的关键经验教训，以及这些经验教训如何为新型肺炎球菌疫苗对肺炎的影响提供见解。回顾了全球范围内Hib疫苗接种在减轻Hib疾病负担和携带方面的价值。通过比较肺炎球菌和Hib的数据，本文得出结论，这些病原体在流行病学和生物学上的差异将使利用Hib疫苗经验结果来预测肺炎球菌结合疫苗引入后的效果变得复杂。
