[Clastogenic effect of trenimon on in vitro chromosomes of phemotypically healthy subjects with morphologically abnormal caryotype].

The effect of a given concentration of Trenimon (6 xpe was analysed in vitro. The research included 6 subjects with balanced translocations, one of them with a centric fusion. Of the remaining 5 subjects, 2 had a duplication in the paracentric region, 1 showed an inversion, and 2 had a marker chromosome. In the group with morphologically abnormal chromosomes a higher sensibility to the influence of Trenimon was found as compared with a control group with morphologically normal karyotype. The subjects with an atypical karyotype had 36 to 65% aberrations, the control group 28%. A localization of the breaks showed no increased aberration rates in the morphologically abnormal chromosomes.