Bolognesi Claudia, Filiberti Rosangela, Neri Monica, Perrone Emanuela, Landini Eleonora, Canessa Pier Aldo, Simonassi Claudio, Cerrano Paolo Giuseppe, Mutti Luciano, Puntoni Riccardo
National Cancer Research Institute, Toxicological Evaluation, 16132 Genoa, Italy.
Cancer Res. 2002 Oct 1;62(19):5418-9.
We evaluated the frequency of micronuclei (MN) in peripheral blood lymphocytes of patients with pleural malignant mesotelioma (MM), lung cancer, benign respiratory diseases, and healthy controls. A significant increased frequency of MN was observed in patients with MM in comparison with all the other groups (median, 11.4 binucleated MN/1000 binucleated cells versus 5.1, 6.1, and 6.2, respectively). No association was found between MN and asbestos exposure. Recently, genetic susceptibility associated with asbestos exposure has been recognized in the development of MM. The presence of high frequency of MN in peripheral blood lymphocytes of patients with MM could represent a useful index of individual susceptibility to this tumor.
我们评估了胸膜恶性间皮瘤（MM）患者、肺癌患者、良性呼吸道疾病患者及健康对照者外周血淋巴细胞中的微核（MN）频率。与所有其他组相比，MM患者中观察到MN频率显著增加（中位数分别为11.4个双核MN/1000个双核细胞，而其他组分别为5.1、6.1和6.2）。未发现MN与石棉暴露之间存在关联。最近，在MM的发生发展中已认识到与石棉暴露相关的遗传易感性。MM患者外周血淋巴细胞中MN的高频率存在可能代表个体对该肿瘤易感性的一个有用指标。
