Kirkov V, Pernov K
Probl Khig. 1975;1:101-6.
The 17-ketosteroid level in the urine secreted in 24 hours s studied in miners with vibration disease. The case material is analyzed according to age, working service, clinical syndromes and stage. It is demonstrated that the continuous effect of local vibrations lead to inhibition of the adrenal function, manifested by a 17-ketosteroids fall. Such a lowering is assumed as one of the adaptational syndrome-manifestations. Regulation of corticosteroid secretion is discussed in the light of complex interrelations--neuroendocrine, biochemical and homeostatic. The role played by oxidation processes is also emphasized. 17-ketosteroids content in the urine has certain diagnostical value, irrespective of the fact that its lowering is by no means a specific manifestation of the vibration disease.
对患有振动病的矿工24小时尿液中分泌的17-酮类固醇水平进行了研究。根据年龄、工作年限、临床综合征和阶段对病例资料进行了分析。结果表明，局部振动的持续作用会导致肾上腺功能受到抑制，表现为17-酮类固醇水平下降。这种下降被认为是适应性综合征的表现之一。从神经内分泌、生化和稳态等复杂的相互关系角度讨论了皮质类固醇分泌的调节。还强调了氧化过程所起的作用。尿液中17-酮类固醇的含量具有一定的诊断价值，尽管其降低绝不是振动病的特异性表现。
