Larraín Camilo
Sección de Hematología, Departamento de Medicina, Hospital Clínico de la Universidad de Chile, Santos Dumont 999, Santiago de Chile.
Rev Med Chil. 2002 Aug;130(8):897-900.
A known hemophiliac B male (blood coagulation factor IX level of 15%), HIV negative, in whom a Philadelphia chromosome positive chronic myeloid leukemia developed at the age of 29 years, is presented. The leukemia was diagnosed after an upper digestive tract bleeding, due to a duodenal ulcer. Two years elapsed between the diagnosis of leukemia and the start of busulfan therapy. During that period and after the start of treatment, the hemorrhagic tendency did not increase. The follow up of the patient was almost 8 years, with favorable clinical response to busulfan therapy. The patient survived more than twice the average survival of chronic myeloid leukemia patients treated with busulfan. A reciprocal influence between chronic myeloid leukemia and hemophilia appears illustrated by this case report.
本文报告一例已知患有B型血友病的男性（凝血因子IX水平为15%），HIV阴性，29岁时发生费城染色体阳性慢性髓性白血病。该白血病在因十二指肠溃疡导致上消化道出血后被诊断出来。白血病诊断与白消安治疗开始之间间隔了两年。在此期间及治疗开始后，出血倾向并未增加。对该患者的随访近8年，白消安治疗取得了良好的临床反应。该患者的存活时间超过了接受白消安治疗的慢性髓性白血病患者平均存活时间的两倍。本病例报告显示了慢性髓性白血病和血友病之间的相互影响。
