Bondar' T P, Pervushin Iu V, Bondareva V P, Lugovskaia S A
Klin Lab Diagn. 2002 Aug(8):15-9.
Anemic syndrome rate in diabetic angiopathy reaching 1/3 in elderly patients, frequency increases after 70 years. The anemic syndrome rate in patients older 60 years suffering from the diabetes mellitus of the 1 type, complicated by "diabetic foot" syndrome and in cases with duration of the disease more than 10 years is elevated. In diabetic angiopathy anemia can be normo- or hypochromic or followed by aniso- or poykilocytosis. Among the causes of anemia in patients with diabetic angiopathies the important place is occupied by mediated by oxidative stress, endotoxicosis and protein glycation prolong hyperglycemia effect on the morphofunctional properties of the red blood cells.
在老年患者中,糖尿病血管病变中的贫血综合征发生率达到三分之一,70岁以后发生率增加。60岁以上患有1型糖尿病并伴有“糖尿病足”综合征且病程超过10年的患者中,贫血综合征发生率升高。在糖尿病血管病变中,贫血可为正色素性或低色素性,或伴有红细胞大小不均或异形红细胞症。在糖尿病血管病变患者贫血的病因中,氧化应激、内毒素血症和蛋白质糖基化介导的长期高血糖对红细胞形态功能特性的影响占据重要地位。