Broadbelt Kevin, Byne William, Jones Liesl B
Department of Biological Sciences, Lehman College, 250 Bedford Park Boulevard, Bronx, New York, NY 10468, USA.
Schizophr Res. 2002 Nov 1;58(1):75-81. doi: 10.1016/s0920-9964(02)00201-3.
A variety of lines of converging evidence implicates the prefrontal cortex (PFC) in schizophrenia. Previous neuroanatomical studies have shown schizophrenia-associated changes in neuron density, soma size and spine number. We recently demonstrated a schizophrenia-associated decrease in microtubule-associated protein 2 (MAP2) immunostaining in laminae III and V of medial prefrontal area 32 and interpreted that finding as suggestive of a loss of dendritic material. We now present data from medial prefrontal area 32 of 11 schizophrenics and 11 comparison subjects. In Golgi-stained material, we describe a significant decrease in the number of both primary (29%) and secondary (46%) basilar dendrites on pyramidal neurons in layer V. Similarly, in layer III there was also a decrease in both primary (17%) and secondary (15%) basilar dendrites. These findings suggest a decrease in synaptic surface area which could lead to aberrant information processing.
一系列相互印证的证据表明，前额叶皮质（PFC）与精神分裂症有关。以往的神经解剖学研究显示，精神分裂症患者在神经元密度、胞体大小和棘突数量方面存在相关变化。我们最近发现，内侧前额叶32区的III层和V层中，与精神分裂症相关的微管相关蛋白2（MAP2）免疫染色减少，我们将这一发现解释为提示树突物质的丢失。我们现在展示了11名精神分裂症患者和11名对照受试者内侧前额叶32区的数据。在高尔基染色材料中，我们发现V层锥体细胞的初级（29%）和次级（46%）基底树突数量均显著减少。同样，在III层，初级（17%）和次级（15%）基底树突也减少。这些发现表明突触表面积减小，这可能导致信息处理异常。
