雌激素治疗对完整大鼠和糖尿病大鼠中DMBA诱导的乳腺肿瘤生长及生物化学的影响(38535)
Effect of estrogen treatment on DMBA-induced mammary tumor growth and biochemistry in intact and diabetic rats (38535).
作者信息
Cohen N D, Hilf R
出版信息
Proc Soc Exp Biol Med. 1975 Feb;148(2):339-43. doi: 10.3181/00379727-148-38535.
Sixty percent of DMBA-induced mammary tumors in Sprage-Dawley rats regress after the animals were made diabetic by treatment with streptozotocin. Administration of estradiol valerate, 1 mg/wk/animal, caused regression of 75% of tumors in intact rats but regression of all tumors in diabetic rats. Estrogen treatment appeared to enhance the effects of diabetes, which by itself resulted in decreased activities of glycolytic enzymes. A role of insulin in growth of DMBA-induced mammary tumors may be warranted.
在用链脲佐菌素使Sprage-Dawley大鼠患糖尿病后，60%由二甲基苯蒽（DMBA）诱导产生的乳腺肿瘤会消退。以每只动物每周1毫克的剂量给予戊酸雌二醇，可使未患糖尿病的大鼠中75%的肿瘤消退，但能使患糖尿病大鼠的所有肿瘤消退。雌激素治疗似乎增强了糖尿病的作用，而糖尿病本身会导致糖酵解酶活性降低。胰岛素在DMBA诱导的乳腺肿瘤生长中可能发挥作用。
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