慢性肾衰竭患者的血浆促红细胞生成素测定
Plasma erythropoietin assay in patients with chronic renal failure.
作者信息
Davies S, Glynne-Jones E, Bisson M, Bisson P
出版信息
J Clin Pathol. 1975 Nov;28(11):875-8. doi: 10.1136/jcp.28.11.875.
Abstract
Using the post-hypoxic mouse method of assay, values for erythropoietin in the plasma of patients with chronic renal failure were equal to, or greater than, normal values. Results suggest that the source of erythropoietin may be primarily extrarenal. Normal renal tissue, provided in the assay by the intact mouse, is required for activation of the hormone. There still remains to be explained the enhanced erythropoietic response to haemorrhage or hypoxia that can occur in anephric man.
摘要
采用缺氧后小鼠检测法，慢性肾衰竭患者血浆中促红细胞生成素的值等于或高于正常值。结果表明，促红细胞生成素的来源可能主要是肾外的。该检测中由完整小鼠提供的正常肾组织是激活该激素所必需的。无肾者对出血或缺氧的促红细胞生成反应增强的现象仍有待解释。
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