Andreani F, Andrisano R, Andreani A
Farmaco Sci. 1975 Oct;30(10):847-58.
Synthesis of some alpha-substituted arylthioacetic acids and esters forming analogues of clofibrate and of nafenopin (SU-13437) is reported and discussed. With a view to evaluating the influence of the introduction of a sulphur atom on the blood-lipid-reducing activity, preliminary pharmacological tests have been carried out on alpha-[4-(1-tetralyl)phenylthio] isobutyric acid (XIV) in parallel with its well-known phenoxy isologue. The results obtained so far, do not show any significant difference between the two compounds.
报道并讨论了一些α-取代芳硫基乙酸及其酯的合成，这些化合物构成了氯贝丁酯和萘酚平（SU - 13437）的类似物。为了评估引入硫原子对降血脂活性的影响，已对α-[4-(1-四氢萘基)苯硫基]异丁酸（XIV）及其著名的苯氧基类似物同时进行了初步药理试验。目前所获得的结果表明，这两种化合物之间没有任何显著差异。
