Shaaban N A, Soliman S I, Mikhail N, Hafez M, Mohareb S W, El-Tahhan H, El-Hammady S
Gaz Egypt Paediatr Assoc. 1975 Jul-Oct;23(3-4):291-7.
Histopathological and histochemical studies were done on renal biopsies taken from twenty nephrotic children and thirty Albino rats of which fifteen were rendered nephrotic by the intravenous injection of nephrotoxic serum and the other fifteen served as controls. There were reduced activities of succinic dehydrogenase, alkaline phosphatase, acid phosphatase and non-specific esterases enzymes. These changes may be secondary to the insult which caused the nephrotic syndrome, or the result of the heavy proteinuria. In conclusion, a derangement in carbohydrate metabolism may underlie the disturbed metabolism of the basement membrane, the distortion of the foot-processes, and the tubular dysfunction.
对20名肾病患儿和30只白化大鼠的肾活检组织进行了组织病理学和组织化学研究，其中15只白化大鼠通过静脉注射肾毒性血清诱导成为肾病大鼠，另外15只作为对照。琥珀酸脱氢酶、碱性磷酸酶、酸性磷酸酶和非特异性酯酶的活性均降低。这些变化可能是导致肾病综合征的损伤的继发结果，或者是大量蛋白尿的结果。总之，碳水化合物代谢紊乱可能是基底膜代谢紊乱、足突扭曲和肾小管功能障碍的基础。
