Genzeli G, Cucchi M L
Virchows Arch A Pathol Anat Histol. 1975;365(3):201-12. doi: 10.1007/BF00434039.
The ultrastructure of rat myocardial capillaries was studied in the course of experimental lathyrism. Endothelial cells were hypertrophic, with a sinuous profile of the plasma membrane facing the lumen and with a consistent increase of pinocytotic vesicles; the nuclei were irregular in shape; ATPase activity was no more demonstrable. Therefore, various and well distinct structural endothelial mechanisms seem to be primarily involved, causing an alteration of the dynamics of transcellular exchanges and of the permeability of the vascular wall. Simultaneous treatment with certain flavonoids, (O-(beta-hydroxyethyl)-rutosides and Na(+)-epicatechin-2-sulfonate), resulted in a less pronounced alteration and a more rapid recovery. The possibility of the existence of a common site of action of lathyrogens and flavonoids is raised in the discussion.
在实验性山黧豆中毒过程中对大鼠心肌毛细血管的超微结构进行了研究。内皮细胞肥大，面向管腔的质膜呈蜿蜒状，吞饮小泡持续增多；细胞核形状不规则；ATP酶活性不再可检测到。因此，各种明显不同的内皮结构机制似乎首先受到影响，导致跨细胞交换动力学和血管壁通透性发生改变。同时用某些黄酮类化合物（O-(β-羟乙基)-芦丁糖苷和Na(+)-表儿茶素-2-磺酸盐）进行治疗，导致变化不那么明显且恢复更快。在讨论中提出了山黧豆毒素和黄酮类化合物存在共同作用位点的可能性。
