Starczewska Barbara, Hałaburda Piotr, Kojło Anatol
Institute of Chemistry, University of Białystok, al J Piłsudskiego 11/4, 15-443 Białystok, Poland.
J Pharm Biomed Anal. 2002 Oct 15;30(3):553-60. doi: 10.1016/s0731-7085(02)00314-x.
Chrome azurol S (CAS) was tested as a spectrophotometric reagent for the determination of imipramine (IMP). It reacts in aqueous media with IMP forming pink-red, sparingly soluble in water ion association compound. This compound was quantitatively extracted with chloroform and the absorbance of organic phase was measured at 510 nm. The extraction conditions were studied using a batch method. On the basis of the results obtained with batch method, three-line flow-injection system was constructed. Batch and flow-injection methods were successfully applied for the determination of IMP in pharmaceutical preparation.
铬天青S（CAS）作为一种用于测定丙咪嗪（IMP）的分光光度试剂进行了测试。它在水性介质中与IMP反应，形成微溶于水的粉红色离子缔合物。该化合物用氯仿进行定量萃取，并在510nm处测量有机相的吸光度。采用分批法研究了萃取条件。基于分批法获得的结果，构建了三线流动注射系统。分批法和流动注射法成功应用于药物制剂中IMP的测定。
