Illigens Ben M, Yamada Akira, Fedoseyeva Eugenia V, Anosova Natalie, Boisgerault Florence, Valujskikh Anna, Heeger Peter S, Sayegh Mohamed H, Boehm Bernhard, Benichou Gilles
Cellular and Molecular Immunology Laboratory, Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA.
Hum Immunol. 2002 Oct;63(10):912-25. doi: 10.1016/s0198-8859(02)00449-4.
In this study, we measured direct and indirect T-cell alloresponses mediated by CD4(+) and CD8(+) T cells in three mouse transplantation models: skin, cornea, and retina. We show that the contribution of direct and indirect antigen recognition pathways to the alloresponse to fully allogeneic grafts varies depending upon the nature of the tissue/organ transplanted. The implications of this finding for understanding the cellular mechanisms by which rejection is mediated in different transplant models are discussed.
