Ramont L, Ngoc P T, Pignon B, Maquart F X
Laboratoire central de biochimie, Hôpital Robert-Debré, Centre hospitalier universitaire, avenue du Général-Koenig, 51092 Reims cedex, France.
Ann Biol Clin (Paris). 2002 Sep-Oct;60(5):565-70.
The interest of serum protein immunofixation in myeloma and Waldenstr m's macroglobulinemia is widely known. It is not so well defined in other malignant hemopathies. The purpose of this study was to determine immunofixation abnormalities in malignant hemopathies other than multiple myeloma and Waldenstr m's macroglobulinemia. We selected serum immunofixations of 61 patients affected by malignant hemopathies and 53 patients affected by other pathologies susceptible to give immunofixation's alterations. We showed that the frequency of immunofixation abnormalities was more important in patients affected by malignant hemopathies than in patients affected by other pathologies (70.5% vs 35.8%). A high frequency of monoclonal immunoglobulins was found in patients with lymphoma (53.3%) and oligoclonal immunoglobulins in other hemopathies (48.2%). No significant difference of the frequency of the monoclonal immunoglobulin isotypes was found. In summary, this retrospective study demonstrates a high frequency of immunofixation abnormalities in malignant hemopathies other than multiple myeloma and Waldenstr m's macroglobulinemia and different immunofixation characteristics between lymphomas and other hemopathies.
血清蛋白免疫固定电泳在骨髓瘤和华氏巨球蛋白血症中的作用已广为人知。而在其他恶性血液病中，其作用尚未明确界定。本研究旨在确定除多发性骨髓瘤和华氏巨球蛋白血症之外的其他恶性血液病中的免疫固定电泳异常情况。我们选取了61例患有恶性血液病的患者以及53例患有其他易导致免疫固定电泳改变疾病的患者的血清免疫固定电泳结果。我们发现，恶性血液病患者中免疫固定电泳异常的频率高于其他疾病患者（70.5%对35.8%）。淋巴瘤患者中发现单克隆免疫球蛋白的频率较高（53.3%），而在其他血液病中寡克隆免疫球蛋白的频率较高（48.2%）。未发现单克隆免疫球蛋白亚型频率存在显著差异。总之，这项回顾性研究表明，除多发性骨髓瘤和华氏巨球蛋白血症之外的其他恶性血液病中免疫固定电泳异常的频率较高，且淋巴瘤与其他血液病之间存在不同的免疫固定电泳特征。
