Dössel O, Sachse F B, Seemann G, Werner C D
Institut für Biomedizinische Technik, Universität Karlsruhe.
Biomed Tech (Berl). 2002 Oct;47(9-10):250-7.
Computer models of the heart can improve the understanding of the electrophysiological processes in healthy and diseased heart. They become more and more important for detailed diagnosis of arrhythmias and for optimization of therapy. Models of myocardium cells known today are described--they are based on the properties of all relevant ion channels in the cell membrane. Then it is demonstrated, how many cells can be joined to form a cell patch and how finally the complete heart can be modelled. A simpler approach is using a so called cellular automation that allows for a significant reduction of calculation time while sacrificing some accordance to reality. Adaptive cellular automations allow for a fast simulation with acceptable accuracy. Using them some results were gained for the simulation of typical arrhythmias, in the field of validation using an animal model and for therapy planning with RF-ablation.
心脏的计算机模型能够增进对健康心脏和患病心脏电生理过程的理解。它们对于心律失常的详细诊断以及治疗优化变得越来越重要。介绍了当今已知的心肌细胞模型——它们基于细胞膜中所有相关离子通道的特性。接着展示了如何将多个细胞连接形成一个细胞片,以及最终如何构建完整心脏的模型。一种更简单的方法是使用所谓的细胞自动机,这在牺牲一定与现实相符度的同时,能显著减少计算时间。自适应细胞自动机能够以可接受的精度进行快速模拟。利用它们在典型心律失常模拟、使用动物模型进行验证以及射频消融治疗规划等方面取得了一些成果。