Malhotra S, Gupta N
Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Eur Child Adolesc Psychiatry. 2002 Jun;11(3):108-14. doi: 10.1007/s00787-002-0270-6.
Childhood disintegrative disorder (CDD), which is classified as a sub-type of pervasive developmental disorder (PDD), has been recognised for many years. Research data on CDD, however, is sparse and it primarily describes the clinical parameters. In this research report clinical data on 12 cases of CDD and 21 cases of typical autism, seen during a specified period, are compared and critically evaluated in reference to the diagnostic criteria in ICD-10 for these disorders. While the findings support the clinical validity of CDD, these also highlight the limitations of the current criteria (ICD-10) particularly the age of onset in CDD and the conceptual confusion in labelling it as a 'PDD'. Need for more research in the areas of the biology, course and outcome of CDD is emphasised.
儿童期崩解性障碍（CDD）被归类为广泛性发育障碍（PDD）的一种亚型，多年来已为人所知。然而，关于CDD的研究数据稀少，主要描述的是临床参数。在本研究报告中，对特定时期内所见的12例CDD病例和21例典型自闭症病例的临床数据进行了比较，并参照ICD - 10中这些障碍的诊断标准进行了批判性评估。虽然研究结果支持CDD的临床有效性，但也凸显了现行标准（ICD - 10）的局限性，特别是CDD的起病年龄以及将其标记为“PDD”时的概念混淆。强调了在CDD的生物学、病程和转归等领域需要开展更多研究。
