拟肽与肽主链修饰
Peptidomimetics and peptide backbone modifications.
作者信息
Ahn Jung-Mo, Boyle Nicholas A, MacDonald Mary T, Janda Kim D
机构信息
Department of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA.
出版信息
Mini Rev Med Chem. 2002 Oct;2(5):463-73. doi: 10.2174/1389557023405828.
PMID:12370047
Abstract
The replacement of the amide bond in a peptide backbone is a widely used form of peptide mimicry. Several of the most common amide bond surrogates, including peptidomimetic work done in this laboratory, and their biological applications are presented in this review.
摘要
肽主链中酰胺键的替换是一种广泛应用的肽模拟形式。本文综述了几种最常见的酰胺键替代物，包括本实验室开展的拟肽研究工作及其生物学应用。
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