Johnson A D, Lonky S A, Carleton R A
Am J Cardiol. 1975 May;35(5):706-9. doi: 10.1016/0002-9149(75)90061-2.
A well documented case of combined hypertrophic subaortic stenosis and calcific aortic stenosis is reported. Detection of multilevel involvement in cases of left ventricular outflow obstruction requires a high index of suspicion and precise hemodynamic and angiographic documentation. Careful analysis of the total data base is necessary for proper management of the patient. The pathogenesis of this combined lesion is unclear: Asymmetrical septal hypertrophy may occur as a consequence of the valvular stenosis, or it may be that abnormal leaflet motion in patients with hypertrophic obstruction produces leaflet thickening, calcification, deformity and stenosis.
本文报告了一例有充分记录的合并肥厚性主动脉瓣下狭窄和钙化性主动脉瓣狭窄的病例。对于左心室流出道梗阻病例中多级受累的检测需要高度的怀疑指数以及精确的血流动力学和血管造影记录。对患者进行妥善管理需要仔细分析全部数据库资料。这种合并病变的发病机制尚不清楚：不对称性室间隔肥厚可能是瓣膜狭窄的结果，或者可能是肥厚性梗阻患者异常的瓣叶运动导致瓣叶增厚、钙化、畸形和狭窄。
