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The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expression.
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13693-8. doi: 10.1073/pnas.212392399. Epub 2002 Oct 7.
3
Replication and subnuclear location dynamics of the immunoglobulin heavy-chain locus in B-lineage cells.
Mol Cell Biol. 2002 Jul;22(13):4876-89. doi: 10.1128/MCB.22.13.4876-4889.2002.

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Nonlinear expression and visualization of nonmetric relationships in genetic diseases and microbiome data.
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Mapping of Replication Origins in the X Inactivation Center of Vole Microtus levis Reveals Extended Replication Initiation Zone.
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Epigenetic Regulation of Individual Modules of the immunoglobulin heavy chain locus 3' Regulatory Region.
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ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis.
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The role of CTCF binding sites in the 3' immunoglobulin heavy chain regulatory region.
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Genome-wide depletion of replication initiation events in highly transcribed regions.
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Decreased replication origin activity in temporal transition regions.
J Cell Biol. 2009 Nov 30;187(5):623-35. doi: 10.1083/jcb.200905144.

本文引用的文献

1
Elucidation of a downstream boundary of the 3' IgH regulatory region.
Mol Immunol. 2003 Jan;39(12):753-60. doi: 10.1016/s0161-5890(02)00256-0.
2
Replication timing and transcriptional control: beyond cause and effect.
Curr Opin Cell Biol. 2002 Jun;14(3):377-83. doi: 10.1016/s0955-0674(02)00326-5.
3
Replication and subnuclear location dynamics of the immunoglobulin heavy-chain locus in B-lineage cells.
Mol Cell Biol. 2002 Jul;22(13):4876-89. doi: 10.1128/MCB.22.13.4876-4889.2002.
5
Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development.
Science. 2002 Apr 5;296(5565):158-62. doi: 10.1126/science.1068768.
7
Stepwise activation of the immunoglobulin mu heavy chain gene locus.
EMBO J. 2001 Nov 15;20(22):6394-403. doi: 10.1093/emboj/20.22.6394.
8
Asynchronous replication and allelic exclusion in the immune system.
Nature. 2001 Nov 8;414(6860):221-5. doi: 10.1038/35102606.
9
Making sense of eukaryotic DNA replication origins.
Science. 2001 Oct 5;294(5540):96-100. doi: 10.1126/science.1061724.
10
Hypermutation: give us a break.
Nat Immunol. 2001 Oct;2(10):902-3. doi: 10.1038/ni1001-902.

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