Woods Steven Paul, Fields Julie A, Tröster Alexander I
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle 98195-6560, USA.
Neuropsychol Rev. 2002 Jun;12(2):111-26. doi: 10.1023/a:1016806711705.
Neuropsychologists are increasingly involved in surgical candidacy evaluations and postoperative neurobehavioral assessments of patients with movement disorders, most notably those with Parkinson's disease (PD). We review here the initial studies regarding neuropsychological outcomes of deep brain stimulation (DBS) within the subthalamic nucleus (STN) for treatment of PD. Overall, these initial investigations provide preliminary support for the cognitive and neurobehavioral safety of STN DBS. Improvements in self-reported symptoms of depression and diminished verbal fluency were the most common findings, whereas changes in global cognitive abilities, memory, attention, and frontal/executive functions were inconsistent and most often described as nominal and/or transient. The generalizability of this literature is hindered by several methodological limitations, including small samples and the absence of appropriate control participants. The clinical and theoretical implications of these initial studies are highlighted and recommendations are offered to guide future research.
神经心理学家越来越多地参与到运动障碍患者的手术候选评估和术后神经行为评估中，尤其是帕金森病（PD）患者。我们在此回顾有关丘脑底核（STN）深部脑刺激（DBS）治疗PD的神经心理学结果的初步研究。总体而言，这些初步研究为STN DBS的认知和神经行为安全性提供了初步支持。最常见的发现是自我报告的抑郁症状有所改善和言语流畅性下降，而整体认知能力、记忆力、注意力和额叶/执行功能的变化并不一致，且大多被描述为轻微和/或短暂的。该文献的普遍性受到若干方法学限制的阻碍，包括样本量小以及缺乏合适的对照参与者。我们强调了这些初步研究的临床和理论意义，并提出了建议以指导未来的研究。
