Carlson Gary P, Ullman Mary, Mantick Nancy A, Snyder Paul W
School of Health Sciences, Purdue University, West Lafayette, Indiana 47907-1338, USA.
Toxicol Pathol. 2002 Sep-Oct;30(5):565-9. doi: 10.1080/01926230290105866.
4-Vinylphenol (4-hydroxystyrene, 4-ethenylphenol, 4-VP) occurs naturally in some foods and has been used as a flavoring agent in food products. It is used synthetically in the production of polymers and resins. It has also been reported to be a minor metabolite of styrene in rats and humans. Varying doses of 4-vinylphenol were administered ip to mice. Hepatotoxicity was assessed by measuring serum sorbitol dehydrogenase (SDH) and by light microscopy. Pneumotoxicity was assessed by measuring proteins, cells, and lactate dehydrogenase activity in bronchoalveolar lavage fluid (BALF) and by light microscopy. 4-VP caused a dose-dependent increase in serum SDH and mild hepatocellular swelling. It caused an increase in cell number and lactate dehydrogenase activity in BALF. Microscopically, there was widespread and severe necrosis of the bronchioles by 12 hours. Re-epithelialzation of the bronchioles was evident by 48 hours. These studies indicate that 4-vinylphenol is both hepatotoxic and pneumotoxic.
4-乙烯基苯酚（4-羟基苯乙烯、4-乙烯基苯酚、4-VP）天然存在于某些食物中，并已被用作食品中的调味剂。它在聚合物和树脂生产中被合成使用。据报道，它也是大鼠和人类体内苯乙烯的一种次要代谢产物。向小鼠腹腔注射不同剂量的4-乙烯基苯酚。通过测量血清山梨醇脱氢酶（SDH）和光学显微镜检查来评估肝毒性。通过测量支气管肺泡灌洗液（BALF）中的蛋白质、细胞和乳酸脱氢酶活性以及光学显微镜检查来评估肺毒性。4-VP导致血清SDH呈剂量依赖性增加以及轻度肝细胞肿胀。它导致BALF中细胞数量和乳酸脱氢酶活性增加。显微镜检查显示，到12小时时细支气管出现广泛而严重的坏死。到48小时时，细支气管重新上皮化明显。这些研究表明4-乙烯基苯酚具有肝毒性和肺毒性。
