Veen W A, Grimbergen A H
Tijdschr Diergeneeskd. 1975 Sep 1;100(17):915-26.
A survey is given of vitamin E and selenium deficiency syndromes in farm animals. Some syndromes can be attributed to the exclusive deficiency of one of the above-mentioned feed components. In some cases with practically complete lack of both componentspathological symptoms can be cured by the addition of one of them to the feed in sufficient amount. A synergistic effect of vitamin E and selenium is sometimes found to recur. The most important theory about the functioning of vitamin E is that it acts as an antioxidant. This theory presumes that, in case of a vitamin E deficiency, peroxidation of unsaturated lipids can occur everywhere in the body leading to oxidative chain reactions. The free radicals thus produced might participate in non-specific reactions with functional and structural compounds. Vitamin E is considered able to reduce lipid peroxides or scavenge free radicals from chain reactions. The pros' and cons' of this theory are discussed. The role of vitamin E has further been associated with thenium is part of the enzyme glutathione peroxidase. This enzyme catalyses the reaction of reduced glutathione with peroxides, whereby hydroxy-acids and oxidized glutathione are generated. Most probably the glutathione peroxidase has its antioxidative action in the cytosol, whereas vitamin E is mainly located in the membranes of the cell.
本文综述了农场动物维生素E和硒缺乏综合征。有些综合征可归因于上述饲料成分之一的单独缺乏。在某些几乎完全缺乏这两种成分的情况下，通过在饲料中添加其中一种足够量的成分，病理症状可以得到治愈。有时会发现维生素E和硒有协同作用。关于维生素E功能的最重要理论是它作为一种抗氧化剂起作用。该理论假定，在维生素E缺乏的情况下，体内各处都可能发生不饱和脂质的过氧化反应，导致氧化链式反应。由此产生的自由基可能参与与功能和结构化合物的非特异性反应。维生素E被认为能够还原脂质过氧化物或清除链式反应中的自由基。本文讨论了该理论的优缺点。维生素E的作用还与硒有关，硒是谷胱甘肽过氧化物酶的一部分。这种酶催化还原型谷胱甘肽与过氧化物的反应，从而生成羟基酸和氧化型谷胱甘肽。谷胱甘肽过氧化物酶很可能在细胞溶质中发挥其抗氧化作用，而维生素E主要位于细胞膜中。
