Green J, Sinclair R D, de Berker D, Sinclair R D
Department of Medicine (Dermatology), University of Melbourne, St. Vincent's Hospital, Fitzroy, Victoria, Australia.
Clin Exp Dermatol. 2002 Sep;27(6):458-60. doi: 10.1046/j.1365-2230.2002.01052.x.
Pili annulati is a distinctive autosomal dominant hair shaft disorder that produces alternating light and dark bands that can give a spangled appearance to the hair. The literature contains three case reports of patients in whom the condition has disappeared following recovery from alopecia totalis. None of these reports contain a direct microscopic comparison of pre- and post-regrowth hairs. We report a 6-year-old girl who was first noted to have pili annulati at the age of 2 years and who developed alopecia totalis at the age of 3 years. When the hair regrew spontaneously, 18 months later, the pili annulati was no longer visible. Hair samples obtained before and after the episode of alopecia areata were compared by normal and cross-polarized light microscopy. While not apparent on careful clinical examination, banding was present on light microscopy in 20% of the hairs. Eighty per cent of the affected hairs displayed banding throughout their entire length. In contrast, prior to the episode of alopecia totalis, when the pili annulati was clearly visible, 50% of the hair obtained was banded on microscopy and 90% of the affected hairs showed banding throughout their microscopic length.
竹节状发是一种独特的常染色体显性遗传性毛干疾病，可产生明暗相间的条纹，使头发呈现出闪烁的外观。文献中有3例斑秃患者在病情恢复后竹节状发消失的病例报告。这些报告均未对再生前后的毛发进行直接的显微镜比较。我们报告了一名6岁女孩，她在2岁时首次被发现患有竹节状发，3岁时出现全秃。18个月后头发自发再生时，竹节状发不再可见。通过普通光镜和偏光显微镜对斑秃发作前后获取的毛发样本进行了比较。虽然仔细的临床检查未发现明显异常，但光镜检查发现20%的毛发存在条纹。80%的受累毛发在整个长度上都有条纹。相比之下，在全秃发作之前，竹节状发清晰可见时，显微镜检查发现所取毛发中有50%有条纹，90%的受累毛发在整个显微镜下长度上都有条纹。
