Leman J A, Dick D C, Morton C A
University Department of Dermatology, Western Infirmary, Glasgow, UK.
Clin Exp Dermatol. 2002 Sep;27(6):516-8. doi: 10.1046/j.1365-2230.2002.01119.x.
Therapeutic options for cutaneous T cell lymphoma (CTCL) include topical steroids, topical chemotherapy and phototherapy. Patients with limited disease that is unresponsive to these therapies present a particular challenge. We report successful treatment of a patient with two plaques of CTCL using topical photodynamic therapy (PDT). 5-aminolaevulinic acid (5-ALA) was applied 6-24 h preillumination with 100 J/cm2 red light. Treatment was repeated on four occasions with clinical and histological clearance. ALA-PDT may be a useful addition to the therapeutic options for CTCL. Further studies are required to define optimal treatment protocols.
皮肤T细胞淋巴瘤（CTCL）的治疗选择包括局部使用类固醇、局部化疗和光疗。对于疾病局限且对这些治疗无反应的患者来说，是一项特殊挑战。我们报告了一名患有两块CTCL斑块的患者通过局部光动力疗法（PDT）成功治愈的病例。在光照前6 - 24小时应用5-氨基酮戊酸（5-ALA），光照强度为100 J/cm²红光。治疗重复进行了4次，临床和组织学上均清除。ALA-PDT可能是CTCL治疗选择中的一个有用补充。需要进一步研究来确定最佳治疗方案。
