Yeates Todd O
UCLA Molecular Biology Institute and Department of Chemistry and Biochemistry, UCLA-DOE Center for Genomics and Proteomics, 611 Charles Young Dr. East, Box 951570, Los Angeles, CA 90095, USA.
Cell. 2002 Oct 4;111(1):5-7. doi: 10.1016/s0092-8674(02)01010-3.
Proteins bearing the widely distributed SET domain have been shown to methylate lysine residues in histones and other proteins. In this issue, three-dimensional structures are reported for three very different SET domain-containing proteins. The structures reveal novel folds for several new domains, including SET, and provide early insights into mechanisms of catalysis and molecular recognition in this family of enzymes.
带有广泛分布的SET结构域的蛋白质已被证明可使组蛋白和其他蛋白质中的赖氨酸残基甲基化。在本期中，报道了三种截然不同的含SET结构域蛋白质的三维结构。这些结构揭示了包括SET在内的几个新结构域的新折叠方式，并为该酶家族的催化机制和分子识别提供了早期见解。
