子宫内膜异位症患者接受促性腺激素释放激素类似物超长效术后治疗后妊娠率增加。
Increased pregnancy rates after ultralong postoperative therapy with gonadotropin-releasing hormone analogs in patients with endometriosis.
作者信息
Rickes Dagmar, Nickel Ingrid, Kropf Siegfried, Kleinstein Jürgen
机构信息
Clinic for Reproductive Medicine and Gynecologic Endocrinology, Faculty of Medicine, Otto-von-Guericke University, Magdeburg, Germany.
出版信息
Fertil Steril. 2002 Oct;78(4):757-62. doi: 10.1016/s0015-0282(02)03338-1.
OBJECTIVE
To examine whether ultralong GnRH analog (GnRH-a) therapy after surgical treatment of endometriosis and before ART influences the pregnancy rate.
DESIGN
Prospective, randomized, controlled study.
SETTING
University clinic for reproductive medicine and gynecologic endocrinology.
PATIENT(S): One hundred ten patients with stage II to IV endometriosis according to ASRM criteria.
INTERVENTION(S): Fifty-five patients received GnRH-a for 6 months after surgery and subsequently underwent up to 3 cycles of ART, and 55 patients received 3 cycles of ART alone immediately after surgery.
MAIN OUTCOME MEASURE(S): Clinical pregnancy rates.
RESULTS
The pregnancy rate per patient was higher among patients who received follow-up treatment with GnRH-a. The same results were found in patients with stage III or IV endometriosis who were undergoing IUI or IVF/ICSI.
CONCLUSION(S): Ultralong GnRH-a therapy increases the pregnancy rate of ART in patients with severe endometriosis.
目的
探讨子宫内膜异位症手术治疗后且在辅助生殖技术（ART）之前进行超长促性腺激素释放激素类似物（GnRH-a）治疗是否会影响妊娠率。
设计
前瞻性、随机、对照研究。
地点
大学附属生殖医学与妇科内分泌诊所。
患者
根据美国生殖医学学会（ASRM）标准，110例II至IV期子宫内膜异位症患者。
干预措施
55例患者术后接受GnRH-a治疗6个月，随后接受多达3个周期的ART；55例患者术后立即单独接受3个周期的ART。
主要观察指标
临床妊娠率。
结果
接受GnRH-a后续治疗的患者中，每位患者的妊娠率更高。在接受宫内人工授精（IUI）或体外受精/卵胞浆内单精子注射（IVF/ICSI）的III或IV期子宫内膜异位症患者中也发现了相同结果。
结论
超长GnRH-a治疗可提高重度子宫内膜异位症患者ART的妊娠率。
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