Novel nucleotide phosphonate analogues with potent antitumor activity.
作者信息
Bubenik Monica, Rej Rabindra, Nguyen-Ba Nghe, Attardo Giorgio, Ouellet France, Chan Laval
机构信息
Shire BioChem Inc., 275 Armand-Frappier Blvd., Laval, Québec, Canada H7V 4A7.
出版信息
Bioorg Med Chem Lett. 2002 Nov 4;12(21):3063-6. doi: 10.1016/s0960-894x(02)00679-0.
Abstract
We have identified several nucleotide phosphonates demonstrating in vitro antiproliferative activity in several human cancer cell lines with IC(50) values in the microM range. The synthesis as well as structure-activity relationship are described.
摘要
Zotero 插件