应激诱导的压力性利钠作用受损会增加非裔美国青少年的心血管负荷。
Impaired stress-induced pressure natriuresis increases cardiovascularload in African American youths.
作者信息
Harshfield Gregory A, Wilson Martha E, Hanevold Coral, Kapuku Gaston K, Mackey Lynne, Gillis Delores, Treiber Frank A
机构信息
Georgia Prevention Institute, Augusta, USA.
出版信息
Am J Hypertens. 2002 Oct;15(10 Pt 1):903-6. doi: 10.1016/s0895-7061(02)02994-1.
BACKGROUND
We hypothesized that impaired stress-induced pressure natriuresis increases blood pressure (BP) load.
METHODS
The 118 African American youths were brought into similar levels of sodium balance. The protocol consisted of a 2-h baseline period, a 1-h stress period (competitive video games), and a 2-h recovery period.
RESULTS
Normal pressure natriuresis (n = 80) resulted from a resistance-mediated (r = 0.23; P <.03) increase in BP (P <.001). In contrast, impaired pressure natriuresis (n = 38), leading to an extended period of elevated BP (P <.05), resulted from a volume-mediated (r = 0.55; P <.002) increase in BP (P <.001).
CONCLUSIONS
Impaired stress-induced pressure natriuresis may contribute to the development of essential hypertension, particularly in African Americans.
背景
我们推测应激诱导的压力性利钠功能受损会增加血压负荷。
方法
118名非裔美国青年被调整至相似的钠平衡水平。实验方案包括2小时的基线期、1小时的应激期（竞争性电子游戏）和2小时的恢复期。
结果
正常压力性利钠（n = 80）是由阻力介导的血压升高（r = 0.23；P <.03）所致（P <.001）。相比之下，压力性利钠功能受损（n = 38）导致血压升高时间延长（P <.05），这是由容量介导的血压升高（r = 0.55；P <.002）所致（P <.001）。
结论
应激诱导的压力性利钠功能受损可能导致原发性高血压的发生，尤其是在非裔美国人中。
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